- Title
- Combinatorial treatment using bevacizumab/pemetrexed loaded core-shell silica nanoparticles for non-small cell lung cancer
- Creator
- Radhakrishnan, Deepika; Patel, Vaishwik; Mohanan, Shan; Wong, Sharon; Netherton, Jacob; Karakoti, Ajay; Vinu, Ajayan
- Relation
- Science and Technology of Advanced Materials Vol. 24, Issue 1, no. 2274819
- Publisher Link
- http://dx.doi.org/10.1080/14686996.2023.2274819
- Publisher
- Taylor & Francis
- Resource Type
- journal article
- Date
- 2023
- Description
- Non-small cell lung cancer (NSCLC) is a life-threatening cancer associated with a higher mortality rate. Despite promising results shown by combination therapies, there remains a need for efficient drug delivery materials capable of combining various drugs, imaging agents, and targeting agents to enhance treatment efficacy. In this study, we present the synthesis of novel core-shell hollow mesoporous silica nanoparticles (@MSN) with bimodal porosity and a large surface area (694 m2/g) to facilitate targeted drug delivery for NSCLC treatment. The hollow core-shell structure enables the loading of a substantial quantity of the pemetrexed drug, up to 839 µg/mg, with a sustained release of 20% within 48 h. The MSN is surface functionalised with amino and carboxyl groups to accommodate an imaging agent and facilitate the attachment of the targeting drug bevacizumab. These particles exhibit rapid uptake by both A549 and PC-9 cells. Moreover, the targeting by bevacizumab leads to higher cytotoxicity within 48 h and induces apoptosis more effectively than the non-functionalised samples. As a versatile drug delivery platform, the hollow core-shell MSN demonstrated in this study holds great potential for various drug delivery applications.
- Subject
- non-small cell lung cancer (NSCLC); combinatorial treatment; core-shell silica nanoparticles; cancer treatment; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1503770
- Identifier
- uon:55394
- Identifier
- ISSN:1468-6996
- Rights
- © 2023 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
- Language
- eng
- Full Text
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